A novel and unique active (*) integrating dermal and epidermal activities

(*) Integrine-60 ® (Patented TM of Vevy Europe, Genova, Italy)


Several research projects are aimed at developing bioactive materials to enhance keratinocytes and/or fibroblasts activities. One promising methodology, widely adopted to identify active substances, is the screening of natural extracts and the isolation of the targeted active compounds from them. Rice (Oryza sativa L.) is a worldwide basic food and many studies highlighted the benefits associated to rice proteins but there is still much to find out about their functional properties.
After a long focused and systematic research, Vevy Europe isolated a novel compound named “Oligopeptide 43785” (**). This specific low molecular weight (avg <1kDa) oligopeptide of rice pure protein was obtained by controlled enzymatic hydrolysis through proteases from botanical source.

It was demonstrated that Oligopeptide 43785 stimulates the synthesis of Fibronectin, Elastin, Collagen type I, IV, VII and XIII in cultured human keratinocytes and fibroblasts, potentially leading to an improvement of the Extra Cellular Matrix (ECM) and thus to dermis eutrophism.

In addition to this, it stimulates Filaggrin production and this could lead to support the homeostasis of the upper layers of the epidermis and a substantial increase of the Natural Moisturizing Factor (NMF), which means a greater moisturization of the epidermis.

(**) “Oligopeptide 43785” is the active component of Integrine®-60 (Vevy codex 18.5500).