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Diabetic Skin: targeted soothing and support

Published on Issues - Year 2018
Authors Vincenzo P.M. Rialdi , Paolo U. Giacomoni  

Introduction In 2014, the prevalence of diabetes-linked pathologies was estimated to be of the order of 420 million worldwide, up from 108 million in 1980 (1). That is to say that one person out of sixteen is suffering from a diabetic pathology. In particular, the prevalence of diabetes in adu...

Tags extracellular matrix, Filagrinol, soothing, diabetes, skin aging, advanced glycation endproducts, glucose, Collagenon, mmp, lang_en, Trioxene-LV, matrix metallo proteinases, Folliculitis, Erythrasma, collagen, Haemochromatosis, moisturization, micro-angiopathy, Hyperpigmented atrophic lesions, Necrobiosis lipoidica diabeticorum, skin resiliency, elasticity, Xanthoma, Perforating dermatosis, Persistent erythema, Acanthosis nigricans, Salycuminol, anti-inflammatory, Diabetic ulcers, elastic fibers, Diabetic dermopathy, dermis, Dermonectin, glycation, Aminoefaderma, fibronectin, Extensive Granuloma Annulare, AGEs, Diabetic skin, Porphyria Cutanea Tarda, Scleredema diabeticorum, curcumin, Hyaluramine-S, Carotenodermia, ACS-AntiCytoStressor, Diabetic bullae, keratinization


Cute diabetica supporto ed interventi mirati

Published on Issues - Year 2018
Authors Vincenzo P.M. Rialdi , Paolo U. Giacomoni;  

INTRODUZIONE La patologia diabetica nelle sue varianti affligge oltre quattrocentoventi milioni (2014) di soggetti nel mondo, contro i centootto milioni del 1980(1). Vale a dire che una persona su sedici soffre di una patologia diabetica. In particolare l'incremento fra gli adulti di oltre diciotto...

Tags extracellular matrix, Filagrinol, soothing, diabetes, skin aging, advanced glycation endproducts, glucose, lang_it, Collagenon, mmp, lang_en, Trioxene-LV, matrix metallo proteinases, Folliculitis, Erythrasma, collagen, Haemochromatosis, moisturization, micro-angiopathy, Hyperpigmented atrophic lesions, Necrobiosis lipoidica diabeticorum, skin resiliency, elasticity, Xanthoma, Perforating dermatosis, Persistent erythema, Acanthosis nigricans, Salycuminol, anti-inflammatory, Diabetic ulcers, elastic fibers, Diabetic dermopathy, dermis, Dermonectin, glycation, Aminoefaderma, fibronectin, Extensive Granuloma Annulare, AGEs, Diabetic skin, Porphyria Cutanea Tarda, Scleredema diabeticorum, curcumin, Hyaluramine-S, Carotenodermia, ACS-AntiCytoStressor, Diabetic bullae, keratinization


Activities of Excipients for Topical Skin Care Formulations

Published on Issues - Year 2017
Author Paolo U. Giacomoni  

INTRODUCTION Far from being inactive bystanders of the pharmacological activity, excipients can play relevant roles in skin care products. Aesthetically pleasing emulsions owe their light touch or sensual feeling to carefully selected excipients able to improve spreadability without diminishing vis...

Tags rheological, acetylated Glycol Stearate, lang_en, emulsifier, dispersion, Xalifin-15, stability, eudermic, oil, wax, absorption, peroxides, saturated, C12-20 Acid PEG-8 Ester, comedogenic, Cetacene, coefficient octanol / water, penetration, C10-18 Triglycerides, sensory, Nesatol, Excipients, plasticity, sebum-like, vehiculation safety, bioemulgoid


Auxina - Effects on human hair and beard growth by topical application of a calibrated blend of botanical extracts (*)

Published on Issues - Year 2016
Author Paolo U. Giacomoni  

A remarkable segment of the personal care market is represented by personal care products for men. It has been estimated that this market (~4 bn $ in the USA alone in 2013 and perhaps six-seven times larger, worldwide) is comparable, in size, to the budget of the National Insitutes of Health...

Tags normalization, scalp, exogen, lang_en, kenogen, trichogram, follicle, flavonoids, adenylate cyclase, stimulation, re-growth, hairs, estrone, auxina tricogena, beard, alopecia, telogen, azelaic acid, growth, hair, anagen, catagen, 5-alpha-reductase


Human Stratum Corneum homeostasis: the relevance of filaggrin and of inducers of filaggrin production

Published on Issues - Year 2016
Author Paolo U. Giacomoni  

A remarkable aspect of epidermal physiology is the repair strategy of the stratum corneum: instead of carrying out punctual removal of damage, the stratum corneum undergoes a permanent renewal. In the basal layer individual cells remove DNA damage and "chaperone" damaged proteins to the lysosomes th...

Tags loricrin, Filagrinol, proline, profilaggrin, Factor, UV, keratin, envelope, corneocytes, lang_en, corneum, skin, psoriasis, hydration, Stratum, NMF, ichthyosis, Urocanic, epidermis, histidine, Filaggrin, granulosum, Moisturizing, keratinization, Natural


Physiologic efficacy and harmlessness in cosmetic hair lotions

Published on Editorials  

The role of Auxina Tricogena® In our field, chemistry is closely intertwined with biology, as well as with dermatology, pharmaco-toxicology, and cosmetology. Due to these complex interconnections, one can see how the cynicism of plagiarists can easily be demolished. The consumers’ health is jeopard...

Tags lang_en


Omeostasi dello strato corneo umano: importanza della filaggrina e degli induttori della produzione della filaggrina

Published on Issues - Year 2016
Author Paolo U. Giacomoni  

Un aspetto notevole della fisiologia dell’epidermide si riscontra nell’analisi della strategia di riparazione nello strato corneo: anziché rimuovere i singoli danni, lo strato corneo è sottoposto ad un continuo processo di rinnovamento. Mentre nello strato basale i cheratinociti riparano il DNA e gu...

Tags Filagrinol, Corneociti, UV, Involucro, Epidermide, Idratazione, Loricrina, lang_en, Stratum corneum granulosum, Filaggrina, Psoriasi, NMF, Pelle, Cheratina, Cheratinizzazione, Ittiosi, Istidina, Profilaggrina, Prolina, Urocanico, Natural Moisturizing Factor


Activities to overcome the BSE crisis

Published on Issues - Year 2009
Author Randolph Riemschneider  

As soon as the first BSE-reports were published and the BSE has occurred (1985/86), the author engaged in “BSE research”, especially concerning filtration technique to eliminate infectious material and experiments to find a method to detect BSE in body fluids. Immediate action regarding BSE was a ...

Tags lang_en, rye, respiration increasing factor, BSE, cereal placenta extracts


Vegetal placenta extracts substitute animal placenta extracts

Published on Issues - Year 2008
Author RANDOLPH RIEMSCHNEIDER  

  Placenta Extracts from cereal bran layers, like rye (illustration 1a,b) deliver cell metabolism activating extracts which can substitute animal placenta ones; rye placenta extract: table A: properties, table B: respiration increasing data, table C: metamorphosis acceleration.   Campi_Aggiuntivi...

Tags increasing, lang_en, respiration cereal extracts, factor. BSE, placenta rye


Remarks on biologic evaluation of Protection Factor for sun products

Published on Issues - Year 2004
Author Giorgio Rialdi  

Skin and Sun Radiations. Filtering Power Measurement. The USA (FDA) and the German (DIN) methods. - Type of UV radiation source; - Quantity of product applied; - Radiation time increase on different skin areas; - SPF calculation; - Standard Reference Product; - MED Evaluation Time; - Type of Skin; -...

Tags DIN, lang_en, UV radiation, OTC, sun, sunscreens, SPF